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The lack of apparent land movement along the New Madrid fault system has
long puzzled scientists. In 2009 two studies based on eight years of GPS
measurements indicated that the faults were moving at no more than 0.2
millimetres (0.0079 in) a year.[

-- wiki


The underlying cause of New Madrid earthquakes is not well understood, but
modern faulting seems to be related to an ancient geologic feature buried
under the Mississippi River alluvial plain,

--wiki

Earlier qs:

AD 1450, AD 900. -- Jay Feldman, "When the Mississippi ran Backwards" 2005

CommercialAppeals.Com ("fizzled.txt") adds 2350 BC!!

Feldman, Dec 15/16 2 AM 1811 "..there was a sudden loud rumbling, likened
in many eyewitness accounts to distant thunder, or the rolling of wagons
across pavement, or a deafening crash resembling 'the discharge of heavy
artillery.'" 

sounds like Tunguska.